Karthus Mid Lane is ranked Off Meta Tier and has a 43.96% win rate in LoL Ultimate Spellbook Patch 14.21. We've analyzed 105 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Malignance, Sorcerer's Shoes, Blackfire Torch, Liandry's Torment, Shadowflame, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Doran's Ring, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Katarina and Yasuo. Karthus's Best Spellbook Mid Lane counters are Diana, Lux, and Swain.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Item Purchase Order
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32003600Karthus Ultimate Spellbook Stats
Karthus Trinkets
Karthus Boots
Karthus Situational Items
Average Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate with Karthus)
Below Average Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(under 49% win rate with Karthus)
Even Mid Lane Matchups for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate for Karthus)
