Karthus Mid Lane is ranked B Tier and has a 50.97% win rate in LoL Ultimate Spellbook Patch 14.21. We've analyzed 1483 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Malignance, Sorcerer's Shoes, Blackfire Torch, Liandry's Torment, Shadowflame, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Sapphire Crystal, and Glowing Mote. Karthus's Best Spellbook Mid Lane matchups include Talon, Kayle, and Varus. Karthus's Best Spellbook Mid Lane counters are Morgana, Irelia, and Galio.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Item Purchase Order
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32003600Karthus Ultimate Spellbook Stats
Karthus Trinkets
Karthus Boots
Karthus Situational Items
Average Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate with Karthus)
Even Mid Lane Matchups for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate for Karthus)
