Tier: DWin47.99%Role7.79%Pick0.14%Ban0.71%Games: 301KDA: 2.21Score: 49.22
Karthus Mid Lane is ranked D Tier and has a 47.99% win rate in LoL Patch 25.04. We've analyzed 301 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Malignance, Archangel's Staff, Sorcerer's Shoes, Liandry's Torment, Shadowflame, and Zhonya's Hourglass. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Flash and Ignite. Starting items should include Doran's Ring, Health Potion, and Stealth Ward. Karthus's Best Mid Lane matchups include Aurelion Sol, Zoe, and Akshan. Karthus's Best Mid Lane counters are Ahri, Annie, and Irelia.
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Karthus Summoner Spells


Win %
Pick %
46%
80%
47%
39%

48%
37%

49%
28%

41%
10%

56%
5%
Karthus Starting Items
Win %
Buy %


2

51%
68%


2

39%
18%
Karthus Runes
Win %
Pick %
40%
48%
57%
15%
54%
12%
92%
3%
Karthus Items

51%

49%

49%

50%

57%

48%

45%

49%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Q | Q | Q | Q | Q | |||||||||||||
![]() | W | W | W | W | W | |||||||||||||
![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order


























Karthus Trinkets
Win %
Buy %

45%
91%

51%
40%

45%
4%
Karthus Boots
Win %
Buy %

49%
75%

32%
6%

100%
0%

0%
1%

0%
1%
Karthus Situational Items
Win %
Buy %

61%
20%

40%
27%

55%
14%

46%
9%

71%
5%

71%
2%