Tier: DWin38.98%Role7.70%Pick0.11%Ban0.46%Games: 275KDA: 2.00Score: 40.72
Karthus Mid Lane is ranked D Tier and has a 38.98% win rate in LoL Patch 25.06. We've analyzed 275 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Malignance, Sorcerer's Shoes, Archangel's Staff, Liandry's Torment, Zhonya's Hourglass, and Shadowflame. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Flash and Ignite. Starting items should include Doran's Ring, Health Potion, and Stealth Ward. Karthus's Best Mid Lane matchups include Akshan, Ekko, and Irelia. Karthus's Best Mid Lane counters are LeBlanc, Yone, and Ahri.
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Karthus Summoner Spells


Win %
Pick %
42%
69%
48%
48%

42%
36%

37%
37%

44%
6%

38%
3%
Karthus Starting Items
Win %
Buy %


2

44%
72%


2

40%
16%
Karthus Runes
Win %
Pick %
41%
47%
44%
21%
62%
4%
51%
5%
Karthus Items

40%

43%

48%

44%

59%

56%

41%

52%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Q | Q | Q | Q | Q | |||||||||||||
![]() | W | W | W | W | W | |||||||||||||
![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order


























Karthus Trinkets
Win %
Buy %

41%
86%

45%
35%

42%
7%
Karthus Boots
Win %
Buy %

43%
71%

26%
7%

0%
0%

0%
0%
Karthus Situational Items
Win %
Buy %

54%
23%

52%
22%

41%
10%

50%
5%

56%
3%

67%
2%