Tier: Off MetaWin22.22%Role4.31%Pick0.11%Ban3.09%Games: 10KDA: 1.97Score: 42.13
Karthus Mid Lane is ranked Off Meta Tier and has a 22.22% win rate in LoL Patch 25.04. We've analyzed 10 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Rylai's Crystal Scepter, Malignance, Sorcerer's Shoes, Shadowflame, Liandry's Torment, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Flash and Exhaust. Starting items should include Doran's Ring, Health Potion, and Stealth Ward.
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Karthus Summoner Spells
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Win %
Pick %
22%
90%
50%
20%
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11%
90%
Karthus Starting Items
Win %
Buy %


2

14%
70%


0%
10%
Karthus Runes
Win %
Pick %
100%
10%
15%
68%
0%
10%
0%
10%
Karthus Items

50%

29%

29%

33%

67%

33%

20%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Q | Q | Q | Q | Q | |||||||||||||
![]() | W | W | W | W | W | |||||||||||||
![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order








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
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
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



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

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
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Karthus Trinkets
Win %
Buy %

20%
100%

33%
30%
Karthus Boots
Win %
Buy %

29%
70%
Karthus Situational Items
Win %
Buy %

0%
10%

0%
10%

0%
40%

0%
20%

0%
10%