Karthus Mid Lane is ranked B Tier and has a 54.35% win rate in LoL Patch 7.24. We've analyzed 46 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Rod of Ages, Sorcerer's Shoes, Morellonomicon, Archangel's Staff, Zhonya's Hourglass, and Void Staff. For runes, the strongest choice is Sorcery (Primary) with Arcane Comet (Keystone), and <pathBonus><pathSorcery>Sorcery</pathSorcery> + <pathInspiration>Inspiration</pathInspiration> </pathBonus> (Secondary). The optimal Summoner Spells for this build are Flash and Teleport. Starting items should include Health Potion, Doran's Ring, The Dark Seal, Refillable Potion, and Warding Totem (Trinket). Karthus's Best Mid Lane matchups include Orianna. Karthus's Best Mid Lane counters are Yasuo and Azir.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Trinkets
Karthus Boots
Average Jungle Duo Queue Champions for Karthus Mid Lane(49% - 51% win rate with Karthus)
Best Mid Lane Matchups for Karthus Mid Lane(over 51% win rate for Karthus)
Even Mid Lane Matchups for Karthus Mid Lane(49% - 51% win rate for Karthus)
