Vayne Mid Lane is ranked Off Meta Tier and has a 51.41% win rate in LoL Patch 9.24. We've analyzed 6755 Vayne Mid Lane games to compile our statistical Vayne Build Guide. For items, our build recommends: Berserker's Greaves, Blade of the Ruined King, Guinsoo's Rageblade, Phantom Dancer, Rapid Firecannon, and Infinity Edge. For runes, the strongest choice is Precision (Primary) with Press the Attack (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Flash and Heal. Starting items should include Health Potion, Doran's Blade, Doran's Shield, Long Sword, and Warding Totem (Trinket). Vayne's Best Mid Lane matchups include Quinn, Taliyah, and Tristana. Vayne's Best Mid Lane counters are Karma, Karthus, and Wukong.
Vayne Summoner Spells
Vayne Starting Items
Vayne Runes
Vayne Items
Vayne Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Vayne Trinkets
Vayne Boots
Average Jungle Duo Queue Champions for Vayne Mid Lane(49% - 51% win rate with Vayne)
Even Mid Lane Matchups for Vayne Mid Lane(49% - 51% win rate for Vayne)
