Karthus Support is ranked Off Meta Tier and has a 66.18% win rate in LoL Patch 8.24. We've analyzed 406 Karthus Support games to compile our statistical Karthus Build Guide. For items, our build recommends: Luden's Echo, Sorcerer's Shoes, Remnant of the Watchers, Morellonomicon, Liandry's Torment, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Flash and Exhaust. Starting items should include Health Potion, Spellthief's Edge, Doran's Ring, Refillable Potion, and Warding Totem (Trinket). Karthus's Best Support matchups include Neeko, Thresh, and Nami. Karthus's Best Support counters are Braum, Brand, and Blitzcrank.
Karthus Summoner Spells






Karthus Starting Items





Karthus Runes
Karthus Items








Karthus Skill Order
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Karthus Trinkets



Karthus Boots



